The untamed frontier has never been so wild. Bill Tyler (Academy Award winner Charlton Heston) and Henry Frapp (Brian Keith) are The Mountain Men, the roughest, toughest pair of fur trappers who ever trekked across the North American wilderness. But while masters in the fields of shooting, drinking and cussing, their greatest talents lie in outrunning hostile Indians- an activity that takes up most of their time. So when they learn that their latest traveling companion, Running Moon (Victoria Racimo), is really a chief's runaway squaw, Bill and Henry must decide what's more important: the girl or their scalps. The Mountain Men soon agree on the only honorable course of action- to put as much distance between Running Moon and themselves as possible.